Melting point: <50 °C
alpha D20 -32.0° (c = 1 in chloroform)
storage temp. 2-8°C
solubility DMSO: 19 mg/mL
Orlistat blocks some of the fat that you eat, keeping it from being
absorbed by your body.
Orlistat is used to aid in weight loss, or to help reduce the risk
of regaining weight already lost. This medicine must be used
together with a reduced-calorie diet. Orlistat is for use only in
Xenical is the prescription-strength form of orlistat. The alli
brand is available without a prescription.
|Appearance||white or almost white crystalline powder,smell less|
The result of HPLC is consisitent to the reference one.
The result of IR is consisitent to the reference one.
|Related Substances||≤ 0.5%|
|Total impurity||≤ 1.0%|
|Single impurity||≤ 0.1%|
|Isopropyl ether||≤ 5000ppm|
|Residual on Ignition||≤0.1%|
|Heavy Metal||≤ 20ppm|
|Purity||≤ 99.0% ~ 99.9%|
The use of orlistat is contraindicated in patients with chronic
malabsorption syndrome or cholestasis. Organic causes of obesity,
such as hypothyroidism, should be excluded before prescribing
Gastrointestinal effects may increase when orlistat is taken with
any one meal high in fat.
Orlistat may reduce the absorption of some fat-soluble vitamins and
beta-carotene. In addition, levels of vitamin D and beta-carotene
may often be low in obese patients. To ensure adequate nutrition,
supplementation with a multivitamin is recommended. The supplement
should be taken at least two hours before or after the
administration of orlistat, such as at bedtime.
Elevated levels of urinary oxalate may develop in some patients
treated with orlistat. Cases of oxalate nephrolithiasis and oxalate
nephropathy with renal failure have been reported. In patients at
risk for renal impairment, it is recommended that renal function be
monitored. Caution should be exercised when prescribing orlistat to
patients with a history of hyperoxaluria or calcium oxalate
Improved control of diabetes may accompany the weight-loss seen
with orlistat. A dosage reduction of oral hypoglycemics or insulin
may be needed.
There is an increased risk of cholelithiasis with substantial